Titers of SARS-CoV-2 IgM and IgG. The time courses for the serum titers of SARS-CoV-2 IgM and IgG at each time point (number of days after symptom onset) are shown in Fig. 1.Only data for which
Anti-SARS-CoV-2 Antibody Levels. Anti-SARS-CoV-2 antibody levels (IgG, IgM, and IgA) were tracked for 14 days after reported symptom onset in 8 patients hospitalized for Covid-19 infection who had never received a SARS-CoV-2 vaccination, for 42 days after 1 st vaccination in 8 volunteers who had no SARS-CoV-2 exposure history and received both doses of the BNT162b2 series, and for 10 daysSARS-CoV-2 has spread across the globe rapidly, causing a worldwide pandemic 1.Infection with this highly contagious respiratory virus can be asymptomatic or present as COVID19, a disease with Anti SARS-CoV-2 kualitatif mendeteksi antibodi terhadap protein nucleocapsid (N), sedangkan pemeriksaan anti SARS-CoV-2 kuantitatif mendeteksi antibodi terhadap protein Spike-RBD. Receptor binding domain (RBD) protein spike (S) SARS-CoV-2 digunakan oleh virus untuk masuk ke dalam sel manusia melalui ikatan dengan reseptor ACE-2. Anti-SARS-CoV-2 antibodies appear quite late, i.e., a few days after clinical manifestations, which is why serological tests cannot be used as a basic tool in diagnosing SARS-CoV-2 infections . The detection of specific anti-SARS-CoV-2 antibodies is possible about 10 days after the first clinical manifestations of infection.
The anti-SARS-CoV-2 IgG antibodies response peaked at 45 days POD but showed overall response till 124 days. The binding IgG antibody concentration correlated with protective immunity. The decline in IgM antibody after 35 days POD and the rare appearance up to 90 POD reemphasizes that detection of IgM antibody may not be reliable in active case
The authors reported a sensitivity of 100% and 88% for detecting SARS-CoV-2 IgG and IgM in COVID-19 patients (7, 8). In the current study, we showed that the BIOSYNEX COVID-19 BSS IgM/IgG rapid test cassette is congruent with the fully automated MAGLUMI 2019-nCoV, in detecting SARS-CoV-2 antibodies.